{"id":21489,"date":"2026-07-26T16:59:12","date_gmt":"2026-07-26T16:59:12","guid":{"rendered":"https:\/\/quickmeals.milaf.ma\/?p=21489"},"modified":"2026-07-26T16:59:12","modified_gmt":"2026-07-26T16:59:12","slug":"for-decades-alzheimers-disease-has-often-been-described-as-an-inevitable-see-more","status":"publish","type":"post","link":"https:\/\/quickmeals.milaf.ma\/index.php\/2026\/07\/26\/for-decades-alzheimers-disease-has-often-been-described-as-an-inevitable-see-more\/","title":{"rendered":"For decades, Alzheimer&#8217;s disease has often been described as an inevitable&#8230;&#8230;..See more"},"content":{"rendered":"<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">For decades, Alzheimer&#8217;s disease has often been described as an inevitable consequence of aging. Research from Harvard Medical School, published in 2025 in the journal Nature, has identified a potential new mechanism involved in the disease: the reduction of natural levels of lithium in the brain. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">The study suggests that, during the early stages of cognitive decline, beta-amyloid plaques may bind some of the lithium present in the brain, reducing its availability to nerve cells. In experiments conducted by the researchers, lithium deficiency was associated with inflammation, synapse alterations, and increased accumulation of beta-amyloid and tau protein. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Lithium is an element naturally present in the body in minute amounts and may contribute to several processes beneficial to brain health. This, however, does not mean that its deficiency has been proven to be the sole or primary cause of Alzheimer&#8217;s, a complex disease influenced by age, genetics, cardiovascular health, lifestyle, and numerous other factors. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Researchers also tested lithium orotate in mouse models of Alzheimer&#8217;s disease. At very low doses, the compound reduced some brain changes, improved synapse function, and partially recovered memory in the animals. The doses used were much lower than those used in psychiatric therapy with other lithium salts. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">These results are interesting, but it is important to note that they were obtained primarily in mice. Currently, lithium orotate has not been proven to prevent, treat, or reverse Alzheimer&#8217;s disease in humans. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">The claim that these doses are completely safe also cannot be extended to humans. Lithium can interfere with kidney and thyroid function, alter electrolytes, and interact with various medications. Furthermore, lithium orotate supplements should not be taken alone for the purpose of protecting memory or treating dementia. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">The research, however, opens up an important avenue: controlled clinical trials will be needed to determine whether lithium levels can become a useful biomarker and whether low-dose formulations can be effective and safe in humans. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">The discovery does not yet represent a cure, but it offers a new hypothesis to be explored in research on brain aging and Alzheimer&#8217;s disease. <\/span><\/span><br class=\"html-br\" \/><br class=\"html-br\" \/><span class=\"html-span xexx8yu xyri2b x18d9i69 x1c1uobl x1hl2dhg x16tdsg8 x1vvkbs x3nfvp2 x1j61x8r x1fcty0u xdj266r xat24cr xm2jcoa x1mpyi22 xxymvpz xlup9mm x1kky2od\"><img loading=\"lazy\" decoding=\"async\" class=\"xz74otr x15mokao x1ga7v0g x16uus16 xbiv7yw\" src=\"https:\/\/static.xx.fbcdn.net\/images\/emoji.php\/v9\/tdc\/1\/16\/26a0.png\" alt=\"\u26a0\ufe0f\" width=\"16\" height=\"16\" \/><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0Medical warning: Do not take lithium or supplements containing it without medical advice and supervision. Anyone experiencing memory problems or cognitive changes should consult a doctor for an appropriate evaluation.<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>For decades, Alzheimer&#8217;s disease has often been described as an inevitable consequence of aging. Research from Harvard Medical School, published&hellip;<\/p>\n","protected":false},"author":1,"featured_media":21490,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-21489","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/posts\/21489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/comments?post=21489"}],"version-history":[{"count":1,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/posts\/21489\/revisions"}],"predecessor-version":[{"id":21491,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/posts\/21489\/revisions\/21491"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/media\/21490"}],"wp:attachment":[{"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/media?parent=21489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/categories?post=21489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/quickmeals.milaf.ma\/index.php\/wp-json\/wp\/v2\/tags?post=21489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}